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male wistar rats (12 and 50 weeks, nondiabetic control)  (Charles River Laboratories)

 
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    Charles River Laboratories male wistar rats (12 and 50 weeks, nondiabetic control)
    ( A ) Representative images of immunohistochemical staining of kidneys for STING in healthy and type 2 diabetic humans <t>(left),</t> <t>nondiabetic</t> <t>(Wistar)</t> rats, and rats with type 2 diabetic neuropathy (T2DN) (right). G, glomerulus. Scale bars: 150 μm. ( B ) Examination of CD68 and STING by immunofluorescence microscopy in diabetic human kidney. Scale bars: 50 μm (left) and 5 μm (right). ( C ) Immunohistochemical detection of CD68 in kidneys of old male Wistar and T2DN rats. Scale bar: 150 μm. ( D ) Representative 3D image from a human kidney stained for inactive and active STING molecules. Scale bar: 2 μm. ( E ) Immunohistochemical staining for mtTFA and TREX1 in renal cortical sections from healthy and diabetic human kidneys. Scale bars: 150 μm. ( F ) Western blot analysis of mtTFA and TREX1 in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. β-Actin was used as a loading control. ( G ) Summary graphs of relative abundance for Western blots shown above. ( H and I ) Western blot analysis of the cGAS/STING pathway molecules (cGAS, STING, p-TBK1, TBK1, p-IRF3, and IRF3) in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. Data presented as mean ± SEM. Statistical analysis was performed using unpaired, 2-tailed Student’s t test. * P < 0.05, ** P < 0.01, **** P < 0.0001. NS, nonsignificant; a.u., arbitrary units.
    Male Wistar Rats (12 And 50 Weeks, Nondiabetic Control), supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Images

    1) Product Images from "Role of cGAS/STING pathway in aging and sexual dimorphism in diabetic kidney disease"

    Article Title: Role of cGAS/STING pathway in aging and sexual dimorphism in diabetic kidney disease

    Journal: JCI Insight

    doi: 10.1172/jci.insight.174126

    ( A ) Representative images of immunohistochemical staining of kidneys for STING in healthy and type 2 diabetic humans (left), nondiabetic (Wistar) rats, and rats with type 2 diabetic neuropathy (T2DN) (right). G, glomerulus. Scale bars: 150 μm. ( B ) Examination of CD68 and STING by immunofluorescence microscopy in diabetic human kidney. Scale bars: 50 μm (left) and 5 μm (right). ( C ) Immunohistochemical detection of CD68 in kidneys of old male Wistar and T2DN rats. Scale bar: 150 μm. ( D ) Representative 3D image from a human kidney stained for inactive and active STING molecules. Scale bar: 2 μm. ( E ) Immunohistochemical staining for mtTFA and TREX1 in renal cortical sections from healthy and diabetic human kidneys. Scale bars: 150 μm. ( F ) Western blot analysis of mtTFA and TREX1 in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. β-Actin was used as a loading control. ( G ) Summary graphs of relative abundance for Western blots shown above. ( H and I ) Western blot analysis of the cGAS/STING pathway molecules (cGAS, STING, p-TBK1, TBK1, p-IRF3, and IRF3) in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. Data presented as mean ± SEM. Statistical analysis was performed using unpaired, 2-tailed Student’s t test. * P < 0.05, ** P < 0.01, **** P < 0.0001. NS, nonsignificant; a.u., arbitrary units.
    Figure Legend Snippet: ( A ) Representative images of immunohistochemical staining of kidneys for STING in healthy and type 2 diabetic humans (left), nondiabetic (Wistar) rats, and rats with type 2 diabetic neuropathy (T2DN) (right). G, glomerulus. Scale bars: 150 μm. ( B ) Examination of CD68 and STING by immunofluorescence microscopy in diabetic human kidney. Scale bars: 50 μm (left) and 5 μm (right). ( C ) Immunohistochemical detection of CD68 in kidneys of old male Wistar and T2DN rats. Scale bar: 150 μm. ( D ) Representative 3D image from a human kidney stained for inactive and active STING molecules. Scale bar: 2 μm. ( E ) Immunohistochemical staining for mtTFA and TREX1 in renal cortical sections from healthy and diabetic human kidneys. Scale bars: 150 μm. ( F ) Western blot analysis of mtTFA and TREX1 in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. β-Actin was used as a loading control. ( G ) Summary graphs of relative abundance for Western blots shown above. ( H and I ) Western blot analysis of the cGAS/STING pathway molecules (cGAS, STING, p-TBK1, TBK1, p-IRF3, and IRF3) in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. Data presented as mean ± SEM. Statistical analysis was performed using unpaired, 2-tailed Student’s t test. * P < 0.05, ** P < 0.01, **** P < 0.0001. NS, nonsignificant; a.u., arbitrary units.

    Techniques Used: Immunohistochemical staining, Staining, Immunofluorescence, Microscopy, Western Blot, Control



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    ( A ) Representative images of immunohistochemical staining of kidneys for STING in healthy and type 2 diabetic humans <t>(left),</t> <t>nondiabetic</t> <t>(Wistar)</t> rats, and rats with type 2 diabetic neuropathy (T2DN) (right). G, glomerulus. Scale bars: 150 μm. ( B ) Examination of CD68 and STING by immunofluorescence microscopy in diabetic human kidney. Scale bars: 50 μm (left) and 5 μm (right). ( C ) Immunohistochemical detection of CD68 in kidneys of old male Wistar and T2DN rats. Scale bar: 150 μm. ( D ) Representative 3D image from a human kidney stained for inactive and active STING molecules. Scale bar: 2 μm. ( E ) Immunohistochemical staining for mtTFA and TREX1 in renal cortical sections from healthy and diabetic human kidneys. Scale bars: 150 μm. ( F ) Western blot analysis of mtTFA and TREX1 in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. β-Actin was used as a loading control. ( G ) Summary graphs of relative abundance for Western blots shown above. ( H and I ) Western blot analysis of the cGAS/STING pathway molecules (cGAS, STING, p-TBK1, TBK1, p-IRF3, and IRF3) in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. Data presented as mean ± SEM. Statistical analysis was performed using unpaired, 2-tailed Student’s t test. * P < 0.05, ** P < 0.01, **** P < 0.0001. NS, nonsignificant; a.u., arbitrary units.
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    Image Search Results


    ( A ) Representative images of immunohistochemical staining of kidneys for STING in healthy and type 2 diabetic humans (left), nondiabetic (Wistar) rats, and rats with type 2 diabetic neuropathy (T2DN) (right). G, glomerulus. Scale bars: 150 μm. ( B ) Examination of CD68 and STING by immunofluorescence microscopy in diabetic human kidney. Scale bars: 50 μm (left) and 5 μm (right). ( C ) Immunohistochemical detection of CD68 in kidneys of old male Wistar and T2DN rats. Scale bar: 150 μm. ( D ) Representative 3D image from a human kidney stained for inactive and active STING molecules. Scale bar: 2 μm. ( E ) Immunohistochemical staining for mtTFA and TREX1 in renal cortical sections from healthy and diabetic human kidneys. Scale bars: 150 μm. ( F ) Western blot analysis of mtTFA and TREX1 in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. β-Actin was used as a loading control. ( G ) Summary graphs of relative abundance for Western blots shown above. ( H and I ) Western blot analysis of the cGAS/STING pathway molecules (cGAS, STING, p-TBK1, TBK1, p-IRF3, and IRF3) in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. Data presented as mean ± SEM. Statistical analysis was performed using unpaired, 2-tailed Student’s t test. * P < 0.05, ** P < 0.01, **** P < 0.0001. NS, nonsignificant; a.u., arbitrary units.

    Journal: JCI Insight

    Article Title: Role of cGAS/STING pathway in aging and sexual dimorphism in diabetic kidney disease

    doi: 10.1172/jci.insight.174126

    Figure Lengend Snippet: ( A ) Representative images of immunohistochemical staining of kidneys for STING in healthy and type 2 diabetic humans (left), nondiabetic (Wistar) rats, and rats with type 2 diabetic neuropathy (T2DN) (right). G, glomerulus. Scale bars: 150 μm. ( B ) Examination of CD68 and STING by immunofluorescence microscopy in diabetic human kidney. Scale bars: 50 μm (left) and 5 μm (right). ( C ) Immunohistochemical detection of CD68 in kidneys of old male Wistar and T2DN rats. Scale bar: 150 μm. ( D ) Representative 3D image from a human kidney stained for inactive and active STING molecules. Scale bar: 2 μm. ( E ) Immunohistochemical staining for mtTFA and TREX1 in renal cortical sections from healthy and diabetic human kidneys. Scale bars: 150 μm. ( F ) Western blot analysis of mtTFA and TREX1 in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. β-Actin was used as a loading control. ( G ) Summary graphs of relative abundance for Western blots shown above. ( H and I ) Western blot analysis of the cGAS/STING pathway molecules (cGAS, STING, p-TBK1, TBK1, p-IRF3, and IRF3) in the kidneys of Wistar and T2DN old male rats. n = 6 rats in each group. Data presented as mean ± SEM. Statistical analysis was performed using unpaired, 2-tailed Student’s t test. * P < 0.05, ** P < 0.01, **** P < 0.0001. NS, nonsignificant; a.u., arbitrary units.

    Article Snippet: Male Wistar rats (12 and 50 weeks, nondiabetic control) were purchased from Charles River Laboratories.

    Techniques: Immunohistochemical staining, Staining, Immunofluorescence, Microscopy, Western Blot, Control

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    doi: 10.3390/ijms22157774

    Figure Lengend Snippet: Gene symbol and name.

    Article Snippet: Three month old, nondiabetic male Wistar rats (Janvier Labs, Saint Berthevin, France) were housed under controlled temperature (22 ± 2 °C) and 12–12 h light-dark cycles rooms with ad libitum access to food and water, and acclimatized for at least 7 days prior to experiments.

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